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RAS BiologyГенетика Russian Journal of Genetics

  • ISSN (Print) 0016-6758
  • ISSN (Online) 3034-5103

Alu polymorphisms of autophagy and apoptosis regulatory genes as human lifespan factors

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PII
S30345103S0016675825010092-1
DOI
10.7868/S3034510325010092
Publication type
Article
Status
Published
Authors
V. V. Erdman
  • Affiliation:
    Institute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences
    Bashkir State Medical University
D. D. Karimov
  • Affiliation:
    Institute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences
    Ufa Research Institute of Occupational Medicine and Human Ecology
I. А. Tuktarova
  • Affiliation: Institute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences
A. A. Petintseva
  • Affiliation: Institute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences
Y. R. Timasheva
  • Affiliation:
    Institute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences
    Bashkir State Medical University
T. R. Nasibullin
  • Affiliation: Institute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences
Volume/ Edition
Volume 61 / Issue number 1
Pages
91-102
Abstract
To assess the contribution to survival of Alu-insertions in the ACE, PLAT, COL13A1, LAMA2, CDH4, SEMA6A, PKHD1L1, STK38L, HECW1, TEAD1 genes, which are candidates of aging and longevity, amid the senile physiological and pathological phenotype, was carried out the association analysis with life expectancy. Survival and mortality data were obtained for 1,382 elderly people, who were selected from the sample of Tatars residing in the Republic of Bashkortostan (total 1790 people from 18 to 109 years). Mortality risk was higher among carriers of the STK38L Alu-insertion genotype (Ya5ac2145*II, HR = 2.07, P = 0.02). Alu-insertion in the HECW1 and TEAD1 genes has demonstrated a survival protection effect (Ya5NBC182*II, HR = 0.71, P = 0.038 and Ya5ac2013*II, HR = 0.74, P = 0.035 respectively). The survival amid the persons with various clinical phenotypes was associated with the Alu polymorphism of the SEMA6A (Yb8NBC597*ID, HR = 0.54, P = 0.016 for the cerebrovascular diseases), TEAD1 (Ya5ac2013*II, HR = 0.57, P = 0.016 for the cardiovascular pathologies) and LAMA2 (Ya5-MLS19*ID, HR = 0.36, P = 0.03 for multimorbidity status) genes. Thus, the genes involved in the regulation of autophagy and apoptosis were associated with survival and longevity.
Keywords
старение долголетие Alu-полиморфизм гены TEAD1 HECW1 STK38L LAMA2 SEMA6A анализ выживаемости
Date of publication
01.01.2025
Year of publication
2025
Number of purchasers
0
Views
21

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