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RAS BiologyГенетика Russian Journal of Genetics

  • ISSN (Print) 0016-6758
  • ISSN (Online) 3034-5103

Effect of RNA Interference-Induced Knockdown of the Actin Gene on Mortality of the German Cockroach,

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PII
S3034510325090041-1
DOI
10.7868/S3034510325090041
Publication type
Article
Status
Published
Authors
K.A. Kosherova
  • Affiliation: Yavilov Institute of General Genetics, Russian Academy of Sciences
N.V. Roshina
  • Affiliation:
    Yavilov Institute of General Genetics, Russian Academy of Sciences
    National Research Centre "Kurchatov Institute"
A.V. Symonenko
  • Affiliation: National Research Centre "Kurchatov Institute"
D.V. Mukha
  • Affiliation: Yavilov Institute of General Genetics, Russian Academy of Sciences
Volume/ Edition
Volume 61 / Issue number 9
Pages
47-55
Abstract
At present, the development of environmentally friendly bioinsecticides for the control of agricultural insect pests and synanthropic insect species is of particular relevance. One promising approach is to use double-stranded RNA complementary to a vital insect gene to knockdown that gene through an RNA interference mechanism, resulting in the death of the insect. Using as a model object, one gene, , was selected from six paralogous actin genes based on the fact that knockdown of this gene in most tissues results in insect death. A double-stranded RNA complementary to the gene of the German cockroach, Blattella germanica, was microinjected under the cuticle. RNA interference of this gene has been shown to kill cockroaches within few weeks. The prospects of using double-stranded RNA complementary to the gene as an insecticide are discussed.
Keywords
РНК-интерференция актин рыжий таракан Blattella germanica уничтожение насекомых-вредителей модельные объекты Drosophila melanogaster
Date of publication
11.03.2026
Year of publication
2026
Number of purchasers
0
Views
23

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