- PII
- S3034510325120081-1
- DOI
- 10.7868/S3034510325120081
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 61 / Issue number 12
- Pages
- 82-89
- Abstract
- The analysis of the thermoreceptor gene (rs322937) was carried out in 15 population samples (1503 people) belonging to different language groups living in the regions of the Altai-Sayan Highlands, Western Siberia, the Far East and Canada. The highest frequency of the rare allele was found in the Yakuts (42.9%), and the lowest in the Eskimos (10.7%) and Evenks (10.8%). Deviations from the Hardy-Weinberg equilibrium were found in the population of Siberian Tatars. The greatest interpopulation differences were found between the Yakuts and Evenks, and the smallest between the Kazakhs, Telengits and Khakass, Telengits and Tatars, Khakass and Nanai, Tuvans and Northern Altaians. Transassociation of polymorphic loci of the , , and genes was carried out using the regression analysis method. Of the six pairs, a positive correlation was found in 3: , and . Thus, the gene studied by us is positively correlated with and and negatively with . The results obtained may indicate different selective pressure in different geographical areas determined by climatic factors.
- Keywords
- гены семейства терморецепторов TRP сибирские популяции полиморфные варианты
- Date of publication
- 17.06.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 27
References
- 1. Clapham D.E. TRP channels as cellular sensors // Nature. 2003. V. 426. P. 517–552. https://doi.org/10.1038/nature02196
- 2. Clapham D.E., Julius D., Montell C., Schultz G. International union of pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels // Pharmacol. Rev. 2005. V. 57. № 4. P. 427–450. https://doi.org/10.1124/pr.57.4
- 3. Mulier M., Vriens J., Voets T. TRP channel pores and local calcium signals // Cell Calcium. 2017. V. 66. P. 19–24. doi.org/10.1016/j.ceca.2017.04.007
- 4. Smani T., Shapovalov G., Skryma R. et al. Functional and physiopathological implications of TRP channels // Biochim. Biophys. Acta. 2015. V. 1853. P. 1772–1782. https://doi.org/10.1016/j.bbamcr.2015.04.016
- 5. Nilius B., Owsianik G., Voets T., Peters J. Transient receptor potential cation channels in disease // Physiol. Rev. 2007. V. 7. P. 165–217. https://doi.org/10.1152/physrev.00021.2006
- 6. Caterina M.J., Schumacher M.A., Tominaga M. et al. The capsaicin receptor: A heat-activated ion channel in the pain pathway // Nature. 1997. V. 389. P. 816–824. https://doi.org/10.1038/39807
- 7. Liu B., Qin F. Single-residue molecular switch for high-temperature dependence of vanilloid receptor TRPV3 // Proc. Natl Acad Sci. USA. 2017. V. 114. P. 1589–1594. https://doi.org/10.1073/pnas.1615304114
- 8. Peier A.M., Reeve A.J., Andersson D.A. et al. A heat-sensitive TRP channel expressed in keratinocytes // Science. 2002. V. 296. P. 2046–2049. https://doi.org/10.1126/science.1073140
- 9. Xu H., Ramsey I.S., Kotecha S.A. et al. TRPV3 is a calcium-permeable temperature-sensitive cation channel // Nature. 2002. V. 418. P. 181–186. https://doi.org/10.1038/nature00882
- 10. Smith G.D., Gunthorpe M.J., Kelsell R.E. et al. TRPV3 is a temperature-sensitive vanilloid receptor-like protein // Nature. 2002. V. 418. P. 186–190. https://doi.org/10.1038/nature00894
- 11. McKemy D.D., Neuhausser W.M., Julius D.D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation // Nature. 2002. V. 416. P. 52–58. https://doi.org/10.1038/nature719
- 12. Peier A.M., Moqrich A., Hergarden A.C. et al. A TRP channel that senses cold stimuli and menthol // Cell. 2002. V. 108. P. 705–715. https://doi.org/10.1016/s0092-8674 (02)00652-9
- 13. Story G.M., Peier A.M., Reeve A.J. et al. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures // Cell. 2003. V. 112. P. 819–829. https://doi.org/10.1016/s0092-8674 (03)00158-2
- 14. Губина М.А., Орлов П.С., Бабенко В.Н. и др. Полиморфизм генов терморецепторов TRPV1 и TRPA1 человека в популяциях Алтае-Саянского региона и Дальнего Востока // Генетика. 2018. Т. 54. № 2. С. 243–252.
- 15. Губина М.А., Бабенко В.Н., Губина Е.Ю. Исследование полиморфного варианта гена холодового рецептора TRPM8 (rs7593557) в 15 популяциях Алтае-Саянского региона, Западной Сибири и Дальнего Востока // Генетика. 2024. Т. 60. № 8. С. 74–81.
- 16. Ruhlen M.A. Guide to the World’s Languages. Classification. London, UK: Edward Arnold, 1991. 495 p.
- 17. Greenberg J. Indo-European and its Closest Elatives: The Еurasiatic Family: Grammar. Stanford, CA: Stanford Univ. Рress, 2000. 345 p.
- 18. Maniatis T., Fritsch E.E., Sambrook J. Molecular Cloning: A Laboratory Manual. N.Y.: Cold Spring Harbor Lab., 1982. 545 p.
- 19. Excoffier L., Lischer H.E. Arlequin suite ver. 3.5: А new series of programs to perform population genetics analyses under Linux and Windows // Mol. Ecol. Res. 2010. V. 10. P. 564–567. https://doi.org/10.1111/j.1755-0998.2010.02847.x
- 20. XLSTAT | Statistical Software for Excel – http://xlstat.com
- 21. The 1000 Genomes Project Consortium. A global reference for human genetic variation // Nature. 2015. V. 526. P. 68–74. https://doi.org/10.1038/nature15393
